Bassia latifolia bud and Cajanus cajan seed were evaluated for antifertility activity in mature male mice . Male antifertility agent affects the count & motility of spermatozoa directly by inhibition of steroidogenesis. Methanol extracts of Bassia latifolia bud and Cajanus cajan seed decreased the sperm count and motility in mature male mice and this may be due to low concentration of fructose levels in the reproductive organs. The reduction in the weight of testis and accessory reproductive organs and the activities of Glucose-6-Phosphate Dehydrogenase (G-6-PDH) and D⁵-3β-Hydroxysteroid Dehydrogenase (D⁵ -3β-HSD) inhibits the androgen biosynthesis in testis. The inhibition of steroidal biosynthesis was responsible for reduction of sperm count and motility. Therefore it may be concluded that the methanol extract of Bassia latifolia bud and Cajanus cajan seed produces antifertility effect on mature male mice.

Keywords: Bassia latifolia; Cajanus cajan; D⁵ -3β-HSD; G-6-PDH; Sperm count; Sperm motility.