Formulation and characterization of an analgesic ointment indicated for pediatric use

Uttam Kumar Mandal^*; Anis Arabi Hashmi; Bappaditya Chatterjee

IKOP Sdn. Bhd., Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200, Kuantan, Pahang, Malaysia.

^* Corresponding author:

Dr. Uttam Kumar Mandal, HOD (R&D Department), IKOP Sdn. Bhd., Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200, Kuantan, Pahang Darul Makmur, Malaysia.

E-mail: mandalju2007@gmail.com, Mobile: +60 109062750, Fax: +60 9571 6775.

Abstract

This research work deals with formulation development and characterization of an analgesic pediatric ointment. The ointment was developed with menthol and camphor as active ingredients at lower concentrations than used for an adult formulation. The formulation was novel as it replaced the oleaginous hydrocarbon petroleum jelly base of conventional ointment by olive oil, a more acceptable excipient to the pediatric patients. The developed formulation was compared against iKOOL, a commercial analgesic ointment with similar composition produced by IKOP Sdn. Bhd., IIUM, Malaysia with respect to various quality control tests. The developed formulation showed encouraging results,but needs further investigation to convert it into a commercial product.

Key words: Analgesic ointment, Menthol, Camphor, Formulation development.

Running title: Analgesic ointment formulation.