Aswini Kumar Senapati1*, Anindya Bose2, Sunil Kumar Kanungo1, Sremantula Satyanarayana3

1 1 Institute of Pharmacy and Technology Salipur, Cuttack, Orissa. 754202, India.

2 Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Dr. Meghnad Saha Sarani, Durgapur-713 206, India.

3 College of Pharmaceutical Sciences, Andhra University, Visakhapatnam. 530003, India.

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The study was designed to investigate the antiulcer activity of Juice, ethanolic (50%) extract and ethanolic (95%) extract of P. acerifolium flower using different models of gastric ulceration in rats. Peptic ulcers were induced by oral administration of aspirin, ethanol and by pyloric ligation. The animals were administered with juice (2 ml/kg, p. o.), ethanolic (50%) extract (400 mg/kg, p. o.) and ethanolic (95%) extract (400 mg/kg, p. o.) before ulcer induction. Omeprazole (20 mg/kg) was used as a reference standard. The antiulcer activity was accessed by determining and comparing the ulcer index in the test group with that of the standard drug treated group. Gastric volume, pH, total acid and free acid were estimated in the pylorus-ligated rats and showed maximum inhibition. The ulcer index in the P. acerifolium treated animals was found to be significantly less in all the models compared to standard drug treated cases. The results suggest that P. acerifolium possesses significant antiulcer property which could be due to cytoprotective action of the drug or strengthening of gastric with the enhancement of mucosal defence.

Keywords: Pterospermum acerifolium, anti-ulcer, pyloric ligation, ulcer index, total acidity, free acidity.

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