A KINETIC STUDY ON THE DISSOLUTION CHARACTERISTICS OF MATRIX
TABLET FORMULATED WITH SALBUTAMOL SULPHATE FOR THE
TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Amitava Ghosh1*, Kaushik Sengupta1
*1Bengal College of Pharmaceutical Sciences & Research, Durgapur, WB
2
Himalayan Pharmacy Institute, Sikkim
Running Title:
Dissolution Kinetics of Matrix tablet
*Corresponding Author:
E-mail Address: amitoli@rediffmail.com
Telephone No: 0343-6511051
Fax No: 0343-2534972
ABSTRACT:
Aims:
The objective of the present study was to develop Salbutamol sulphate
matrix tablet for sustained release dosage form, for the treatment of
Chronic Obstructive Pulmonary Disease (COPD).
Methods:
Simultaneous equations were formed to calculate the concentration values of
Salbutamol sulphate and drug compatibility study was performed through
Infrared spectroscopy. The matrix tablets were prepared by wet granulation
method using two hydrophobic polymers such as Ethyl cellulose and Acrycoat
S-100 in varying ratios. Results and Conclusions: The granules
showed satisfactory flow properties. All the seven tablet formulations
showed acceptable pharmacotechnical properties and complied with the
in-house specifications for tested parameters. The results of formulation
F-4 (Ethyl cellulose and Acrycoat in 2:1 ratio) could extend the release of
Salbutamol sulphate up to 12 hr and was found comparable to marketed
sustained release products. Model fitting analysis (Zero order, Higuchi and
Korsmeyer-Peppas model) for all the formulations were performed and it was
seen that all the formulations predominantly follow the Higuchi model.
While comparing with the ‘n’ values of all the formulations of
Korsmeyer-Peppas model, Fickian/Diffusion controlled release was observed
in case of F-4 and F-5, whereas for the other formulations non-Fickian
transport was observed.
Keywords:
Salbutamol sulphate, matrix tablet, Acrycoat S 100, Ethyl Cellulose,
Fickian Diffusion