Development and evaluation of Ibuprofen-calcium alginate beads
Sanchita Mandal a*, Sanat Kumar Basu b,
a
Division of Pharmaceutics, H.K. College of Pharmacy,
Jogeshwari (w) Mumbai 400102
b
Ex-Professor, Division of Pharmaceutics, Department of Pharmaceutical
Technology, Jadavpur University, Kolkata 700032, India
*Corresponding author: sm_pharm@yahoo.co.in
ABSTRACT
THE objective of this study was to develop a sustained release dosage form
of Ibuprofen (IBP) using a natural polymeric carrier prepared in a
completely aqueous environment. IBP was entrapped in calcium alginate bead
prepared with sodium alginate by ionotropic gelation method using calcium
chloride as a crosslinking agent. The drug was incorporated either into
preformed calcium alginate gel beads (sequential method) or incorporated
simultaneously during the gelation stage (simultaneous method). The beads
were evaluated for particle size and surface morphology using optical
microscopy and SEM respectively. Beads produced by the sequential method
had higher drug entrapment. Drug entrapment in the sequential method
increases with increase in CaCl2 and polymer concentration but
decreased with increase in drug concentration. And in the simultaneous
method drug entrapment increases when polymer and drug concentration were
increased and it increased to a certain extent with increase in CaCl 2 concentration and further increase resulted in lower drug
loading. FTIR studies revealed that there is no interaction between drug
and CaCl2. XRD studies show that crystalline drug changed to
amorphous state after formulation. Release characteristics of the IBP
loaded calcium alginate beads were studied in enzyme free simulated gastric
and intestinal fluid.
Key words:
Sodium Alginate, Calcium alginate bead, Ibuprofen,
ionotropic gelation.