Analytical Platforms Used In The Field of Metabonomics: A Mini Review
Mainak Mal
*
* Research Fellow, National University of Singapore, 21 Lower Kent Ridge
Road, Singapore 119077.
Correspond Author: E-mail:
mainakmal@gmail.com
ABSTRACT
Metabonomics involves metabolic profiling of various biomatrices in
response to any diseased condition or genetic modification or due to effect
of environment or lifestyle related factors With its advent, the field of
metabonomics has made valuable contributions and insight to system biology
research. Metabonomics provides a powerful tool complementary to genomics
and proteomics and can be used to obtain valuable information into
functional biology, toxicology, pharmacology and diagnosis of diseases.
This mini-review briefly describes the advantages, disadvantage and
applications of the various analytical platforms used in metabonomics such
as nuclear magnetic resonance (NMR) spectroscopy, Fourier transform
infrared (FTIR) spectroscopy, LC with ultraviolet or coulometric detection,
capillary electrophoresis (CE) with ultraviolet detection and mass
spectrometry (MS) based techniques like direct infusion MS, gas
chromatography mass spectrometry (GC/MS), liquid chromatography mass
spectrometry (LC/MS) or capillary electrophoresis mass spectrometry
(CE/MS).
Keywords:
metabonomics, analytical techniques, NMR, GC/MS, LC/MS