Analytical Platforms Used In The Field of Metabonomics: A Mini Review

Mainak Mal *

* Research Fellow, National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077.

Correspond Author: E-mail: mainakmal@gmail.com

ABSTRACT

Metabonomics involves metabolic profiling of various biomatrices in response to any diseased condition or genetic modification or due to effect of environment or lifestyle related factors With its advent, the field of metabonomics has made valuable contributions and insight to system biology research. Metabonomics provides a powerful tool complementary to genomics and proteomics and can be used to obtain valuable information into functional biology, toxicology, pharmacology and diagnosis of diseases. This mini-review briefly describes the advantages, disadvantage and applications of the various analytical platforms used in metabonomics such as nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, LC with ultraviolet or coulometric detection, capillary electrophoresis (CE) with ultraviolet detection and mass spectrometry (MS) based techniques like direct infusion MS, gas chromatography mass spectrometry (GC/MS), liquid chromatography mass spectrometry (LC/MS) or capillary electrophoresis mass spectrometry (CE/MS).

Keywords: metabonomics, analytical techniques, NMR, GC/MS, LC/MS