Enhanced dissolution rate of diclofenac by solid dispersion method
Avik Kumar Saha, Subhabrata Banerjee, Indrani Das, MD. Farque Ansari,
Kaushik Mukherjee*
Dr. B C Roy College of Pharmacy and AHS, Durgapur , 713206.
Corresponding author: kaushik.pharmacyju08@gmail.com
ABSTRACT
The objective of this work was to improve aqueous solubility of poorly
water soluble drugs by a modified porous starch as solid dispersion
carrier. The yield of the porous starch was found to be 80%. The flow
property of the prepared porous starch was found to be good, with good
compressibility index. Drug content of all the formulations were found to
be in the range between 90-100%. The dissolution profile showed that in
solid dispersions prepared by physical mixing process and solvent
evaporation method, the dissolution of pure diclofenac is high in
comparison with the solid dispersion samples. Whereas in solid dispersions
prepared by solvent evaporation method, dissolution of pure diclofenac is
very low in comparison with the solid dispersion samples of drug with
porous starch due to co-habitation of carriers with diclofenac that
improved the dissolution rate of the drug. The predicted drug release
mechanism for solvent evaporation method where the drug release could be by
first order release model. Thus this study confirmed that a porous starch
can be developed and utilized as a carrier to improve the aqueous
solubility of poorly water soluble BCS class II drugs thereby improving its
dissolution rate and bioavailability.
Keywords:
Porous starch, diclofenac, solid dispersion, solubility.