Formulation and Evaluation of Fast Dissolving Tablets of Diclofenac Sodium Using Different Superdisintegrants by Direct Compression Method

Anindya Maity, Sravan Paswan, Avik Kumar Saha*

Dr. B.C.Roy College of Pharmacy & AHS, Bidhannagar, Durgapur-713206



The aim of the present work is to formulate a tablet which disintegrate and dissolve rapidly and give its rapid onset of action: analgesic, antipyretic and anti inflammatory action. Diclofenac sodium is among the most extensively used NSAIDs; employed in muscular skeletal complaints, especially arthritis. Conventional diclofenac sodium tablet available in market are not suitable where quick onset of action is required. Besides, the conventional tablets also show poor patient compliance particularly by geriatric and pediatric patients and those who are suffering from dysphegia, nausea and vomiting. In present study, an attempt had been made to formulate for FDT of diclofenac sodium by using various superdisintegrants like sodium starch glycolate, Sodium carboxymethyl cellulose followed by direct compression technique. The tablets were evaluated for weight variation, hardness, friability, disintegration time, in vitro dissolution studies and drug content. It was concluded that the batch which was prepared by using combination of Sodium carboxymethyl cellulose (NaCMC) and sodium starch glycolate as a superdisintegrant shows excellent disintegration time, enhance dissolution rate, taste masking and hence lead to improve efficacy and bioavaibility of drug.

Keywords: Diclofenac Sodium, Fast dissolving tablet (FDT), Superdisintegrant.

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