Isoquinoline derivatives as caspase 3 inhibitors-a review

Ismail Modal, Souvik Basak*

Dr. B.C. Roy College of Pharmacy & Allied Health Sciences, Dr. Meghnad Saha Sarani, Bidhannagar, Durgapur-713206


Our study is to investigate the inhibition of apoptosis or program cell death by blocking the activation of Caspase 3. Caspase 3 is belongs to the c ysteine-aspartic acid protease (caspase) family. It is encoded by the CASP3 gene. Caspase-3 initiates apoptotic DNA fragmentation by proteolytically inactivating ICAD. Induction of apoptosis via death receptors typically results in the activation of an initiator Caspase such as Caspase 8 or Caspase 10. These Caspases can then activate other Caspases in a cascade. This cascade eventually leads to the activation of the effector Caspases, such as Caspase 3 and Caspase 6. These Caspases are responsible for the cleavage of the key cellular proteins, such as cytoskeleton proteins, that leads to the typical morphological changes observed in cells undergoing apoptosis. There are several anti apoptic drugs present which inhibit apoptosis by several pathways. Isoquinoline 1,3,4-trione could be used for the blocking of activation of caspase 3. Thus synthesis of isoquinoline 1,3,4- trione & its derivatives could be done. The compound have anti apoptosis property, thus it has also anti inflammatory action, because during apoptosis inflammation takes place.

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