ABSTRACT

Pterospermum acerifolium (L.) Wild. has been reported to possess both wound healing as well as hypoglycemic properties. Hence, an effort has been made to further explore the plant’s efficacy in wound healing in diabetic rodent model. The collected aerial parts of the plant were extracted with methanol. Gels of different concentrations were prepared with ethyl acetate fraction of the methanolic extract of the plant (PAFEF) along with methyl paraben, propyl paraben, carbopol and triethanolamine. The diabetes induced rodents were subjected to various excision (woun d contraction, period of epithelization and hydroxyproline content) and incision (tensile strength) wound healing tests. The parameters were measured using framycetin sulfate cream (1% w/w) as standard. Formulations containing various concentrations of PAFEF were found to increase wound healing on the diabetes induced rodents compared to control. Formulations containing highest concentration of PAFEF showed increased rate of wound contraction demonstrated by enhanced epithelization.

Keywords: ethyl acetate fraction of Pterospermum acerifolium (L.) Willd., wound healing, hydroxyproline content, streptozotocin-induced diabetic rats