UV spectroscopic method for simultaneous estimation of Celecoxib and Amlodipine

Devanshi S Pathak, Prasanna K Pradhan*, Dhananjay B Meshram, Hiral A Patel

Department of Quality Assurance, Pioneer Pharmacy Degree College, Vadodara, Gujarat, India

*Correspondence : prasanna.k.pradhan@gmail.com

Abstract

A simple, precise and accurate First order derivative UV spectroscopic method has been developed for estimation of Celecoxib (CEL) and Amodipine (AML) simultaneously. The linearity was established over the concentration range of 15–40 𝜇 g/mL and 3–8 𝜇 g/mL for CEL and AML respectively. The mean % recoveries were found to be 99.78%for CEL and 100.36% for AML. The proposed method was validated as per ICH guidelines and successfully applied for assay of CEL and AML in their synthetic mixture.

Keywords: Celecoxib, Amlodipine, UV-spectrophotometry