Flavonoids from leaves of Syzygium samarangense and its pharmacological potential: some recent insights

Tatini Debnath*¹, Raja Chakraverty² and Pranabesh Chakraborty³

1Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technolog),

Haringhata, Nadia, India.

2Department of Pharmacology, IPGME&R-SSKM Hospital, Kolkata, India, Kolkata-700020

3Bengal School of Technology (College of Pharmacy),Sugandha, Delhi Road. Hooghly- 712102. West Bengal

Correspondence: Email- dtatini09@gmail.com

Abstract

Syzygium samarangense is an indigenous herb growing ubiquitously in various parts of India. The present review aims to unravel the recent findings with respect to the flavonoids and their bioactivity isolated from the extracts and fractions of this plant. Extensive literature and compendial survey (2001-2019) was performed of existing bibliographic databases such as PubMed, AYUSH, Google scholar and databases of Traditional Knowledge and search strategies were designed a priori. Antibacterial, antifungal and anti-inflammatory activities were reported in Syzygium species. The flavonoids, isolated from Syzygium samarangense, studies were reported to exhibit activities like antidiarrheal, immuno-pharmacological,cytotoxic, antihyperglycaemic, antibacterial activity, analgesic and anti-inflammatory and antioxidant activity.  In recent years many plants extracts containing flavonoids alongwith other secondary metabolites which have free radical scavenging properties accompanied with other activities like anti-inflammatory, hepatoprotective, nephroprotective, antiproliferative, neuroprotective and also cardio protective. The flavonoids fall under the category of typical phenolic compounds and are abundant in plants. The typical characteristic functional group in flavonoids is hydroxyl group substituted flavan moiety. These characteristic functional groups in flavonoids are free radical scavengers that impedes the oxidation of biological molecules following conversion of ROS into inactive species. Hence oxidative stress induced disorder and diseases could be prevented with the help of antioxidants.

Keywords: Flavonoids, bioactive compounds, phytoconstituents, phenol