Arthropods have innumerable species that has been used as the tool for discovery initially on toxicology for extracting venoms. Later multiple species were in the eye of researchers to correlate the genetical and physiological similarity with human and mammalian species. Drosophila was one of the major fly where mainly genetical experimentations were being conducted. Cancer being the one of tributaries of the same which was not only revealed the possibilities of screening model but also emphasized on various pathways of proteomics and drug targets. Our present review were a conglomerate of some of the pharmacological categories that has come up with numerous avenues of preclinical modeling and drug discovery associated with metabolic, cardiovascular, inflammation and infectious disease and depression.