The aim of this review is to briefly illustrate both the advantages and the limitations of using zebrafish as a model system for lifestyle based human diseases and drug discovery. The availability of a model predictive animal model of disease is one of the cornerstone in the drug discovery and development. In this context, bibliographic searches were performed under Pubmed, Medline and Google scholar for articles indexed in these databases ranging from 2001 to 2021. Zebrafish has evolved as a suitable animal model organism for experimental pharmacology is expanding at a great rate to include lifestyle diseases of human. Lifestyle diseases are characterized by conditions which occur in primarily based on the way of living and occupational habits of individuals. Diseases that impact on our daily lifestyle are mainly obesity & diabetes. Nowadays, diabetes & obesity are considered as global epidemics. The prevalence rates of diabetes are increasing day by day in parallel with the rates of obesity. Research is ongoing for surgical and pathological management of obesity and diabetes. For identification and development of effective treatment the use of animal models are important. Zebrafish is poised to present as a unique model for human disease. In this study we discuss the advantages, disadvantages of pathology associated with diabetes & obesity by using zebrafish model. In consideration of these potential shortcomings, it is expected that zebrafish will not replace the classical mammalian test systems anytime soon, but rather complement them as a first step in vertebrate modelling of disease and aid the complex process of drug discovery.