With the increase in lifespan of human being, the probability of suffering from metabolic disorder and lifestyle disease has increased manifold. Across the world, Osteoarthritis is a public health problem. Previously, it is thought to be a wear and tear disease of cartilage but with the advancement of molecular biology it can be known to be disease of polygenic in nature. Obesity related Osteoarthritis (OA) is a metabolic disorder mostly suffered by overweight persons and OA may be a lifestyle disease in some people. There are various types of arthritis affecting mankind and osteoarthritis is one of the common forms of arthritis. Details of signs and symptoms, pathogenesis, treatment, research in the areas of pain management are discussed here.